Sometimes, eating healthy and being active are enough to lower blood sugar levels. But, like many people with type 2 diabetes, you may also need medicine to help control your blood sugar. You may even need more than one medicine to treat the disease in different ways.

AVANDAMET combines two medicines to treat type 2 diabetes–rosiglitazone maleate and metformin (a biguanide)—in one convenient pill:
  • Rosiglitazone helps the body use its own natural insulin better–for improved blood sugar.*
  • Metformin works in a number of ways, but mainly by helping your liver make less sugar.
Only your doctor can decide if AVANDAMET is right for you. AVANDAMET is not right for everyone. Taking AVANDAMET with insulin or nitrates is not recommended.

AVANDARYL combines two medicines to treat type 2 diabetes—rosiglitazone and glimepiride—in one convenient pill:
  • Rosiglitazone helps the body use its own natural insulin better–for improved blood sugar.*
  • Glimepiride helps your body release more insulin.
Only your doctor can decide if AVANDARYL is right for you. AVANDARYL is not right for everyone. Taking AVANDARYL with insulin or nitrates is not recommended.

*Individual results may vary.


See commonly asked questions about AVANDAMET See commonly asked questions about AVANDARYL

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Important Safety Information about AVANDAMET® (rosiglitazone maleate/metformin HCl)

AVANDAMET can cause or worsen heart failure. If you have severe heart failure (very poor pumping ability of the heart), you cannot be started on AVANDAMET. AVANDAMET is also not recommended if you have heart failure with symptoms (such as shortness of breath or swelling), even if these symptoms are not severe.

Rosiglitazone, one of the medicines in AVANDAMET, may increase your risk of other heart problems that occur when there is reduced blood flow to the heart, such as chest pain (angina) or heart attack (myocardial infarction). This risk appeared higher in patients taking medicines called nitrates or insulin.

If you have chest pain or a feeling of chest pressure, you should seek immediate medical attention, regardless of what diabetes medicines you are taking. If you take AVANDAMET, tell your doctor right away if you: have swollen legs or ankles, a rapid increase in weight or difficulty breathing, or unusual tiredness; experience changes in vision; become pregnant.

A small number of people who have taken metformin, another medicine in AVANDAMET, have developed a rare yet serious condition called lactic acidosis (a buildup of lactic acid in the blood) that can cause death. You have a higher chance of getting lactic acidosis if you have kidney problems; have liver problems; drink alcohol very often or excessively; get dehydrated, as when you are sick with a fever, vomiting or diarrhea; or you are going to have surgery. Tell your doctor if you have any of these problems before or while taking AVANDAMET. You should not take AVANDAMET if you have kidney problems or metabolic acidosis. Tests should be used to check your kidneys and liver before and while taking AVANDAMET. If you are taking medicines for heart failure, you may be at increased risk of lactic acidosis.

Call your doctor right away if you feel any of the following, which may be signs of lactic acidosis: very weak or tired; you have unusual (not normal) muscle pain; you have stomach pains; you have trouble breathing; you feel dizzy or lightheaded; or you have a slow or irregular heartbeat.

Before taking AVANDAMET, review your medical history and tell your doctor if you:

  • Have heart failure or other heart problems, or are on any medicines for high blood pressure, high cholesterol or heart failure, or for prevention of heart disease or stroke.
  • Take insulin or nitrate medicines. Taking AVANDAMET with insulin or with nitrates is not recommended.
  • Have kidney problems.
  • Are going to have dye injected into a vein for an X-ray, CAT scan, heart study, or other type of scanning.
  • Drink a lot of alcohol.
  • Develop a serious condition such as a heart attack, severe infection, or a stroke.
  • Are 80 years of age or older.
  • Have a type of diabetic eye disease called macular edema.
  • Have liver problems or had liver problems while taking REZULIN® (troglitazone).
  • Are pregnant or planning to become pregnant.
  • Are breastfeeding or planning to breastfeed.

Women taking AVANDAMET should know that AVANDAMET may increase the risk of pregnancy. More fractures have been observed in women taking AVANDAMET. Other possible side effects of AVANDAMET include anemia, hypoglycemia, diarrhea, nausea, and upset stomach. Your doctor should do blood tests to check your liver before you start AVANDAMET and during treatment as needed.

Prescription AVANDAMET, along with diet and exercise, helps improve blood sugar control in patients with type 2 diabetes. It is a combination of two drugs - rosiglitazone maleate and metformin HCl.

For more information about AVANDAMET, please see
Medication Guide and full Prescribing Information.

Important Safety Information about AVANDARYL® (rosiglitazone maleate and glimepiride)

AVANDARYL can cause or worsen heart failure. If you have severe heart failure (very poor pumping ability of the heart), you cannot be started on AVANDARYL. AVANDARYL is also not recommended if you have heart failure with symptoms (such as shortness of breath or swelling), even if these symptoms are not severe.

Rosiglitazone, one of the medicines in AVANDARYL, may increase your risk of other heart problems that occur when there is reduced blood flow to the heart, such as chest pain (angina) or heart attack (myocardial infarction). This risk appeared higher in patients taking medicines called nitrates or insulin.

If you have chest pain or a feeling of chest pressure, you should seek immediate medical attention, regardless of what diabetes medicines you are taking. If you take AVANDARYL, tell your doctor right away if you: have swollen legs or ankles, a rapid increase in weight or difficulty breathing, or unusual tiredness; experience changes in vision; become pregnant.

AVANDARYL may cause low blood sugar. Lightheadedness, dizziness, shakiness or hunger may mean that your blood sugar is too low. If you have kidney problems, you may need a lower dose of AVANDARYL to reduce problems with low blood sugar. Talk to your doctor if low blood sugar is a problem for you.

Before taking AVANDARYL, review your medical history and tell your doctor if you:

  • Have heart failure or other heart problems, or are on any medicines for high blood pressure, high cholesterol or heart failure, or for prevention of heart disease or stroke.
  • Take insulin or nitrate medicines. Taking rosiglitazone with insulin or with nitrates is not recommended.
  • Have a type of diabetic eye disease called macular edema.
  • Have liver problems or had liver problems while taking REZULIN® (troglitazone).
  • Are pregnant or planning to become pregnant.
  • Are breastfeeding or planning to breastfeed.

Women taking AVANDARYL should know that AVANDARYL may increase the risk of pregnancy. More fractures have been observed in women taking AVANDARYL. Another possible side effect of AVANDARYL is anemia. Your doctor should do blood tests to check your liver before you start AVANDARYL and during treatment as needed.

Prescription AVANDARYL, along with diet and exercise, helps improve blood sugar control in patients with type 2 diabetes. AVANDARYL is a combination of two drugs - rosiglitazone maleate and glimepiride.

For more information about AVANDARYL, please see
Medication Guide and full Prescribing Information.